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Piperacetazine

Piperacetazine
Clinical data
Trade namesActazine, Quide, Psymod
AHFS/Drugs.comInternational Drug Names
Identifiers
  • 1-[10-[3-[4-(2-hydroxyethyl)piperidin-1-yl]propyl]phenothiazin-2-yl]ethanone
CAS Number
PubChem CID
ChemSpider
UNII
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.021.194
Chemical and physical data
FormulaC24H30N2O2S
Molar mass410.58 g·mol−1
3D model (JSmol)
  • CC(=O)c1ccc2Sc3ccccc3N(CCCN4CCC(CCO)CC4)c2c1
  • InChI=InChI=1S/C24H30N2O2S/c1-18(28)20-7-8-24-22(17-20)26(21-5-2-3-6-23(21)29-24)13-4-12-25-14-9-19(10-15-25)11-16-27/h2-3,5-8,17,19,27H,4,9-16H2,1H3
  • Key:BTFMCMVEUCGQDX-UHFFFAOYSA-N

Piperacetazine (Quide) is an antipsychotic prodrug, most notably used for schizophrenia.[1] It is a phenothiazine derivative. Based on clinical trial data, it appears to have similar efficacy as chlorpromazine. However, very little research has been done since the 1970s, and it is not a commonly used drug today.[2]

Side effects

The side effect profile of piperacetazine is similar to that of other typical antipsychotics. The most common side effects of piperacetazine are dizziness, drowsiness, fainting, orthostatic hypotension, and extrapyramidal symptoms. Less common side effects include nausea, vomiting, bradycardia, euphoria, and headache. Rare side effects include leukopenia, thrombocytopenia, galactorrhea, amenorrhea, seizures, urinary retention, and jaundice.[2]

References

  1. ^ Rada RT, Donlon PT (February 1974). "Piperacetazine in ambulatory chronic schizophrenic patients". Current Therapeutic Research, Clinical and Experimental. 16 (2): 124–129. PMID 4156665.
  2. ^ a b Eslami Shahrbabaki M, Dehnavieh R, Vali L, Sharafkhani R (October 2018). "Chlorpromazine versus piperacetazine for schizophrenia". The Cochrane Database of Systematic Reviews. 10 (10): CD011709. doi:10.1002/14651858.CD011709.pub2. PMC 6517193. PMID 30378678.
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