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Copanlisib

Copanlisib
Clinical data
Trade namesAliqopa
Other namesBAY 80-6946
AHFS/Drugs.comMonograph
MedlinePlusa617044
License data
Routes of
administration		Intravenous
Drug classPI3-Kinase inhibitor
ATC code
Legal status
Legal status
Pharmacokinetic data
Protein binding84.2%[1]
MetabolismCYP3A4/5 (≈90%), CYP1A1 (≈10%)[1]
Elimination half-life39.1 hours (range: 14.6 to 82.4)[1]
ExcretionFeces (64%), Urine (22%); 14% were not recovered[1]
Identifiers
  • 2-Amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC23H28N8O4
Molar mass480.529 g·mol−1
3D model (JSmol)
  • COC1=C(C=CC2=C1N=C(N3C2=NCC3)NC(=O)C4=CN=C(N=C4)N)OCCCN5CCOCC5
  • InChI=1S/C23H28N8O4/c1-33-19-17(35-10-2-6-30-8-11-34-12-9-30)4-3-16-18(19)28-23(31-7-5-25-20(16)31)29-21(32)15-13-26-22(24)27-14-15/h3-4,13-14H,2,5-12H2,1H3,(H2,24,26,27)(H,28,29,32)
  • Key:PZBCKZWLPGJMAO-UHFFFAOYSA-N

Copanlisib, sold under the brand name Aliqopa,[1] is a medication used for the treatment of adults experiencing relapsed follicular lymphoma who have received at least two prior systemic therapies.[1][2]

Adverse effects

Data for safety and efficacy of copanlisib are described in the consumer-targeted FDA Drug Trial Snapshot.[3] Copanlisib can cause serious side effects including infections, hyperglycemia, hypertension, pneumonitis, neutropenia and skin rashes. The most common side effects of copanlisib are hyperglycemia, diarrhea, decreased general strength and energy, hypertension, leukopenia, neutropenia, nausea, lower respiratory tract infections and thrombocytopenia. Copanlisib can cause harm to unborn babies.

Mechanism of action

Copanlisib is an inhibitor of phosphatidylinositol-3-kinase (PI3K) with inhibitory activity predominantly against PI3K-α and PI3K-δ isoforms expressed in malignant B-cells. It has been shown to induce tumor cell death by apoptosis and inhibition of proliferation of primary malignant B cell lines.[1]

History

Efficacy resulting in the approval of copanlisib was based on the subgroup of 104 patients with follicular lymphoma from a Phase 2 clinical trial.[4] Of these, 59 percent had a complete or partial shrinkage of their tumors that lasted about 12 months.

To assess the safety of the drug, data from 168 adults with follicular lymphoma and other hematologic malignancies treated with copanlisib were evaluated.[3]

Clinical trials

Phase II clinical trials are in progress for treatment of endometrial cancer,[5] diffuse large B-cell lymphoma,[6] cholangiocarcinoma,[7] and non-Hodgkin lymphoma.[4] Copanlisib in combination with R-CHOP or R-B (rituximab and bendamustine) is in a phase III trial for relapsed indolent non-Hodgkin lymphoma (NHL).[8] Two separate phase III trials are investigating the use of copanlisib in combination with rituximab for indolent NHL[9] and the other using copanlisib alone in cases of rituximab-refractory indolent NHL.[10]

In a preclinical study, copanlisib was effective in inhibiting HER2+ breast cancer cells with acquired resistance to the HER2-inhibitors trastuzumab and/or lapatinib. This effect was increased when copanlisib was administered along with the aforementioned HER2-inhibitors.[11] Consequently, treatments of copanlisib with trastuzumab are being clinically trialled in HER2-positive breast cancer patients.[12]

Society and culture

For follicular lymphoma, the U.S. Food and Drug Administration (FDA) awarded copanlisib orphan drug designation in February 2015, and fast track designation in February 2016.[13] The New drug application for follicular lymphoma was granted priority review in May 2017.[14]

In September 2017, it received accelerated approval for the treatment of adults experiencing relapsed follicular lymphoma who have received at least two prior systemic therapies. Further clinical trials are to be performed as a post-marketing requirement to verify the clinical benefit.[15]

Copanlisib was granted orphan drug status for the treatment of splenic, nodal and extranodal subtypes of marginal zone lymphoma.[14]

References

  1. ^ a b c d e f g h "Aliqopa- copanlisib injection, powder, lyophilized, for solution". DailyMed. 23 February 2022. Retrieved 1 April 2023.
  2. ^ "FDA approves new treatment for adults with relapsed follicular lymphoma" (Press release). U.S. Food and Drug Administration (FDA). 24 March 2020. Retrieved 1 April 2023.
  3. ^ a b "Drug Trials Snapshots Aliqopa". U.S. Food and Drug Administration (FDA). 30 June 2020.
  4. ^ a b Clinical trial number NCT01660451 for "Open-label, Uncontrolled Phase II Trial of Intravenous PI3K Inhibitor BAY80-6946 in Patients With Relapsed, Indolent or Aggressive Non-Hodgkin's Lymphomas" at ClinicalTrials.gov
  5. ^ Clinical trial number NCT02728258 for "Copanlisib in Treating Patients With Persistent or Recurrent Endometrial Cancer" at ClinicalTrials.gov
  6. ^ Clinical trial number NCT02391116 for "Phase II Copanlisib in Relapsed/Refractory Diffuse Large B-cell Lymphoma (DLBCL)" at ClinicalTrials.gov
  7. ^ Clinical trial number NCT02631590 for "Copanlisib (BAY 80-6946) in Combination With Gemcitabine and Cisplatin in Advanced Cholangiocarcinoma" at ClinicalTrials.gov
  8. ^ Clinical trial number NCT02626455 for "Study of Copanlisib in Combination With Standard Immunochemotherapy in Relapsed Indolent Non-Hodgkin's Lymphoma (iNHL)" at ClinicalTrials.gov
  9. ^ Clinical trial number NCT02367040 for "Copanlisib and Rituximab in Relapsed Indolent B-cell Non-Hodgkin's Lymphoma (iNHL)" at ClinicalTrials.gov
  10. ^ Clinical trial number NCT02369016 for "Phase III Copanlisib in Rituximab-refractory iNHL" at ClinicalTrials.gov
  11. ^ Elster N, Cremona M, Morgan C, Toomey S, Carr A, O'Grady A, et al. (January 2015). "A preclinical evaluation of the PI3K alpha/delta dominant inhibitor BAY 80-6946 in HER2-positive breast cancer models with acquired resistance to the HER2-targeted therapies trastuzumab and lapatinib" (PDF). Breast Cancer Research and Treatment. 149 (2): 373–83. doi:10.1007/s10549-014-3239-5. PMID 25528022. S2CID 25568678.
  12. ^ Clinical trial number NCT02705859 for "Phase Ib/II Trial of coPANlisib in Combination With Trastuzumab in HER2-positive Breast Cancer. (Panther Study)" at ClinicalTrials.gov
  13. ^ "NDA 209936, Multisciplinary Review document, chapter 3" (PDF). U.S. Food and Drug Administration (FDA).
  14. ^ a b "Bayer receives FDA approval for Copanlisib in adults with relapsed follicular lymphoma after two prior systemic therapies" (Press release). Bayer AG. 14 September 2017.
  15. ^ "NDA 209936, Approval Letter" (PDF). U.S. Food and Drug Administration (FDA).
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